The Cordillera Huayhuash is a mountain range in the Andes of Peru. Aligned north to south, the main range of some twenty peaks stretches for approximately 25 km, with a subsidiary range of smaller peaks stretching out to the west for approximately 15 km. Six of the peaks exceed 6000 m. Included among them are Yerupaja (6617 m), the second highest mountain in Peru (behind Huascaran at 6768 m), and Siula Grande (6344 m), made famous by Joe Simpson in Touching the Void.

There are many lesser peaks surrounding those covered by ice, and several passes exceeding 5000 m. It is necessary to travel a considerable distance from the central range to find ground lower than 3000 m, even on valley floors, and the Cordillera Huayhuash is often taken to include this much larger area.

The area is barely populated at all, with what hamlets there are being very small and generally only found below 4000 m (the snowline is found at approximately 4800 m). The nearest villages are Chiquian (3400 m) and Cajatambo (3375 m). Some mining takes place in the area, so to the north of the mountains there is an unsurfaced road leading up to as high as 4750 m. In 2002 the Peruvian Ministry of Agriculture declared the Huayhuash a "reserved zone" and prohibited certain economic activities, including any future mining.